The Venture family visits Tijuana, Mexico, where the boys are kidnapped by the Monarch, Brock is buried alive, H.E.L.P.eR. gets a south-of-the-border makeover and Dr. Venture's kidneys are stolen. Also, the Monarch's moving and powerful origin story is revealed.
"Careers in Science"
The Venture family must travel to space to repair an orbiting space station that Dr. Venture's father built in the 1970s. Meanwhile, Hank and Dean investigate the possibility that a mysterious space phantom is haunting the station and Brock's presence adds heat to an already tense romantic relationship between the station's two officers.
"Eeney, Meeney, Miney… Magic"
Dr. Venture's new invention is literally sucking the family in and the Ventures’ strange new neighbor, master of mysticism Dr. Orpheus, could hold the secret to their escape. And his teenaged daughter may hold the secret to Dean's heart.
"The Incredible Mr. Brisby"
Dr. Venture is offered a job by theme park owner and cartoon magnate Roy Brisby, who will not take "no" for an answer in his quest for worldwide entertainment dominance. Meanwhile, Hank and Dean are kidnapped by the Orange County Liberation Front, a group of militant suburbanites who want to take down Brisby's empire in order to save their neighborhood. Brock enlists the aid of former lover and fellow super-spy Molotov Cocktease to rescue the family, but she may have her own fiendish agenda.
"Mid-Life Chrysalis"
The Monarch sends Dr. Girlfriend undercover to seduce Dr. Venture in order to inject him with a body-altering serum. Meanwhile, Brock is depressed to learn that his license to kill has expired, so the boys are determined to help him cram for his government exam.
"Tag Sale -- You're It!"
Always short on cash, Dr. Venture decides to unload some of his father's old scientific equipment in a huge yard sale that attracts fellow scientists and super-villains alike. Everyone is supposed to be on their best behavior, but The Monarch can't resist the temptation to wreak havoc once he finds himself inside the "belly of the beast."
"Home Insecurity"
To protect the Venture compound while Brock is on his yearly mountain survival sabbatical, Dr. Venture builds a panic room and a robotic bodyguard. His security measures are put to the test when both the Monarch's and Baron Ünderbheit's henchmen choose the same night to launch separate attacks. While the villains bicker over who has dibs on the head of Dr. Venture, Brock befriends the strangest couple in the Cascadian Mountains.
"Ghosts of the Sargasso"
On a scientific expedition in the Bermuda Triangle, Dr. Venture’s experimental equipment awakens the submerged ghost of Major Tom, a test pilot who crashed in an experimental aircraft designed by Doc's father. The Ventures’ hydrofoil is hijacked by a group of fake ghost pirates who've been stranded in the sargassum since Jesus Jones was popular.
"Ice Station – Impossible!"
Dr. Venture, Pete White and Master Billy Quizboy are invited to take part in a top-secret government think tank run by super-genius Professor Impossible (coincidentally, their former college mentor.) But Doc's life is in jeopardy once he learns the dark secrets of Impossible's sequestered family. Meanwhile, Hank has become a walking time bomb thanks to a stolen Cold War serum, and Brock and Dean must race the clock to save him.
"Testicular Torsion"
The Monarch finally has the Venture family right where he wants them -- hanging upside down above the Amazon River. But his victory is postponed when Dean suffers a strange but fairly common injury- acute testicular torsion. According to the bylaws of the Guild of Calamitous Intent, a temporary truce must be called in order to get Dean medical attention, so Brock and Hank are held as collateral. Dr. Venture calls on "Boy Genius" Master Billy Quizboy and Mr. White to perform an emergency orchiopexy on Dean, while Brock and Hank get a firsthand look at what goes on at The Monarch's headquarters.
"Past Tense"
When Brock and Dr. Venture are kidnapped at the funeral of a college friend, Hank and Dean enlist the aid of the original Team Venture, the group of adventurers who worked for their grandfather in the ‘60s. Col. Horace Gentleman, martial arts master Kano, The Action Man, and Otto Aquarius (exiled son of Atlantis) regroup to free Brock and "Rusty." Meanwhile, the mysterious kidnapper reveals the secret of his 20-year grudge through a series of flashbacks to when he, Brock, Doc, Baron Ünderbheit and Mr. White were all in college together.
