Premiere: Sunday, September 29 / 8:00 p.m. ET / FOX
This fall, The Simpsons will air the show's twenty-fifth season, a huge milestone for the primetime cartoon. To celebrate, the Simpson family will crossover to two other cartoons: Family Guy and Futurama, which was co-created by Matt Groening. See the Family Guy page in this season premiere guide for more details.
Kristen Wiig (Despicable Me) guest-voices in the season premiere episode as an intense, high-strung FBI agent whom Lisa enlists for help when she suspects that something sinister has happened to Homer.
Also, Elizabeth Moss (Mad Men) plays a grateful mom who names her baby Homer Jr., after Homer Sr. helps in the delivery of the child.
Additional guest voices this season include Zach Galifianakis (The Hangover Part III), Rachel Maddow (The Rachel Maddow Show), legendary Marvel Comics writer Stan Lee, critically acclaimed author Harlan Ellison, Anderson Cooper (Anderson Cooper 360º), Eva Longoria (Desperate Housewives), producer Judd Apatow, Will Arnett (Arrested Development) and Daniel Radcliffe (the Harry Potter series of movies).