In "Weekend at Burnsies" on The Simpsons, Phish guest stars when Homer Simpson is prescribed medical marijuana and becomes addicted. Mr. Burns hopes to use Homer at his shareholder's meeting, making Homer laugh at everything he says, but a new law is passed that prohibits medical marijuana. So Burns fakes his death, but Smithers and Homer animate his body (a la Weekend at Bernie's) and convince the shareholders to continue funding the power plant.

